Compound Detail
CHEMBL427814
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Cc1nc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](N)Cc3ccccc3)CCC(=O)NCCCC[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc3ccccc3)NC2=O)c[nH]1
Basic Information
| ChEMBL ID | CHEMBL427814 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | JYZUNUUQCBCNGE-IMBOPAGWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1145.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocyte-stimulating hormone receptor CHEMBL3795 | EC50 | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocyte-stimulating hormone receptor | EC50 | = | 1.0 | nM | 9.0 | Effective concentration required for maximum agonist response at melanocortin 1 ... | 14998337 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14998337 | 10.1021/jm030452x | Melanocyte-stimulating hormone receptor | 3 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 3 | 1 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine