Compound Detail
CHEMBL4279816
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Basic Information
| ChEMBL ID | CHEMBL4279816 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KLJYFWSBHZTKDU-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
240.3
MW (Da)
2.02
ALogP
4
HBA
1
HBD
78.4
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 4.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | EC50 | 4.81 | 4.81 | 15360.0 | 1 |
| Cerebellar granule neurone CHEMBL614452 | EC50 | 4.81 | 4.81 | 15360.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cerebellar granule neurone | EC50 | = | 15360.0 | nM | 4.81 | Neuroprotective activity against glutamate-induced excitotoxicity in mouse prima... | 30108699 |
| Glutamate receptor ionotropic, NMDA 1 | EC50 | = | 15360.0 | nM | 4.81 | Protective Effects of Compounds on Primary Cerebellum Granule Cells of Rats: Iso... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30108699 | 10.1039/C6MD00509H | Aorta | 3 |
| 30108699 | 10.1039/C6MD00509H | Cerebellar granule neurone | 2 |
Data from ChEMBL 36 via Core Engine