Compound Detail
CHEMBL428973
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C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1cccc2cnccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL428973 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | IEHYLJPTZQIXGJ-DPLGUDNSSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1047.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP-dependent protein kinase (PKA) CHEMBL2094138 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Protein kinase C (PKC) CHEMBL2093867 | IC50 | 4.32 | 4.32 | 48000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP-dependent protein kinase (PKA) | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of cAMP-dependent protein kinase (PKA). | 1992155 |
| Protein kinase C (PKC) | IC50 | = | 48000.0 | nM | 4.32 | Inhibition of protein kinase C (PKC) | 1992155 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1992155 | 10.1021/jm00105a012 | Protein kinase C (PKC) | 1 |
| 1992155 | 10.1021/jm00105a012 | cAMP-dependent protein kinase (PKA) | 1 |
Data from ChEMBL 36 via Core Engine