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Compound Detail

CHEMBL429204

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C=C(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12

Basic Information

ChEMBL ID CHEMBL429204
Phase Preclinical
Structure Type MOL
InChI Key NHZWWMLZMGWNPU-ZZJQNEBHSA-N
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

513.8
MW (Da)
6.21
ALogP
3
HBA
3
HBD
86.6
PSA (Ų)
0.39
QED
2
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H51NO4
MW 513.76
Aromatic Rings 0
Heavy Atoms 37
NP-Likeness 2.50

Activity Summary

EC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
19911773 10.1021/jm900872z G-protein coupled bile acid receptor 1 2
10328313 10.1016/s0960-894x(99)00165-1 SK-MEL-2 1
10328313 10.1016/s0960-894x(99)00165-1 KB 1
10328313 10.1016/s0960-894x(99)00165-1 ADMET 1
19911773 10.1021/jm900872z Bile acid receptor 1

Data from ChEMBL 36 via Core Engine