Compound Detail
CHEMBL429244
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Basic Information
| ChEMBL ID | CHEMBL429244 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AOUNSDICPNJTQM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
412.5
MW (Da)
3.31
ALogP
5
HBA
2
HBD
68.1
PSA (Ų)
0.38
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 7.46 | 7.46 | 35.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.92 | 4.92 | 11900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C (PKC) | IC50 | = | 35.0 | nM | 7.46 | Inhibition of protein kinase C (PKC) in rat brain | 1552513 |
| Unchecked | IC50 | = | 11900.0 | nM | 4.92 | Inhibition of c-AMP dependent protein kinase A (PKA) in bovine heart | 1552513 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1552513 | 10.1021/jm00084a004 | Protein kinase C (PKC) | 1 |
| 1552513 | 10.1021/jm00084a004 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine