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Compound Detail

CHEMBL4292528

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O=C(Cn1cc(-c2ccc(C(=O)O)cc2)nn1)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)OC(C(=O)O)=C[C@@H]1O

Basic Information

ChEMBL ID CHEMBL4292528
Phase Preclinical
Structure Type MOL
InChI Key VSWCXOCNKMYFAQ-NYMASUJMSA-N
0
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

478.4
MW (Da)
-2.43
ALogP
11
HBA
7
HBD
224.6
PSA (Ų)
0.20
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H22N4O10
MW 478.41
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.07

Activity Summary

IC50 4 meas.

Literature References

PubMed DOI Target Context # Activities
30457869 10.1021/acs.jmedchem.8b01411 Sialidase-1 1
30457869 10.1021/acs.jmedchem.8b01411 Sialidase-2 1
30457869 10.1021/acs.jmedchem.8b01411 Sialidase-3 1
30457869 10.1021/acs.jmedchem.8b01411 Sialidase-4 1

Data from ChEMBL 36 via Core Engine