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Compound Detail

CHEMBL4297223

MITAPIVAT SULFATE
💊 Approved Drug
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💊 Approved Drug
O.O.O.O=C(c1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1)N1CCN(CC2CC2)CC1.O=C(c1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1)N1CCN(CC2CC2)CC1.O=S(=O)(O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4297223
Name MITAPIVAT SULFATE
Phase Approved
Structure Type MOL
InChI Key DMRIPASJCJRBMV-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL4299940
Active Moiety CHEMBL4299940

Known Names

AG-348 HEMISULFATE SESQUIHYDRATE AG-348 sulfate hydrate Mitapivat hemisulfate sesquihydrate Mitapivat sulfate Pyrukynd
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
5
Known Names
3
Indications
1
Mechanisms

Molecular Properties

450.6
MW (Da)
3.20
ALogP
5
HBA
1
HBD
82.6
PSA (Ų)
0.62
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2022
Availability Prescription
Chirality Achiral

Routes of Administration

Oral

Flags

First in Class
USAN Stem -pivat
USAN Year 2018

Extended Properties

Molecular Formula C48H60N8O13S3
MW 1053.25
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -1.89

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Pyruvate kinase isozymes R/L activator ACTIVATOR Pyruvate kinase PKLR ✓ ✓

Indications

Anemia, Hemolytic Anemia, Hemolytic, Congenital Genetic Diseases, Inborn

Data from ChEMBL 36 via Core Engine