Compound Detail
CHEMBL4297471
MK-8666 Phase I
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Phase I
Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2cc3c(cn2)[C@H]2[C@@H](C3)[C@@H]2C(=O)O)c1
Basic Information
| ChEMBL ID | CHEMBL4297471 |
| Name | MK-8666 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | CODQKEMYZZKQAE-QPVYNBJUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
1
Known Names
1
Indications
Molecular Properties
521.6
MW (Da)
4.73
ALogP
6
HBA
1
HBD
102.8
PSA (Ų)
0.38
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Diabetes Mellitus, Type 2
Activity Summary
EC50 1 meas. best 8.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Free fatty acid receptor 1 CHEMBL4422 | EC50 | 8.25 | 8.25 | 5.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Free fatty acid receptor 1 | EC50 | = | 5.6 | nM | 8.25 | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing ... | 33769827 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33769827 | 10.1021/acs.jmedchem.1c00031 | Free fatty acid receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine