Compound Detail
CHEMBL4297625
LICOGLIFLOZIN 🧪 Phase II
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🧪 Phase II
CCc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc2c(c1)OCCO2
Basic Information
| ChEMBL ID | CHEMBL4297625 |
| Name | LICOGLIFLOZIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | XFJAMQQAAMJFGB-ZQGJOIPISA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
5
Known Names
5
Indications
2
Mechanisms
Molecular Properties
416.5
MW (Da)
1.13
ALogP
7
HBA
4
HBD
108.6
PSA (Ų)
0.58
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sodium/glucose cotransporter 1 inhibitor | INHIBITOR | Sodium/glucose cotransporter 1 | ✓ | ✓ |
| Sodium/glucose cotransporter 2 inhibitor | INHIBITOR | Sodium/glucose cotransporter 2 | ✓ | ✓ |
Indications
Diabetes Mellitus, Type 2 Kidney Diseases Non-alcoholic Fatty Liver Disease Obesity Polycystic Ovary Syndrome
Activity Summary
IC50 2 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 CHEMBL3884 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| Sodium/glucose cotransporter 1 CHEMBL4979 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 1 | IC50 | = | 0.5 | nM | 9.3 | Inhibition of SGLT1 (unknown origin) | 32738984 |
| Sodium/glucose cotransporter 2 | IC50 | = | 0.5 | nM | 9.3 | Inhibition of SGLT2 (unknown origin) | 32738984 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32738984 | 10.1016/j.bmcl.2020.127387 | Sodium/glucose cotransporter 1 | 1 |
| 32738984 | 10.1016/j.bmcl.2020.127387 | Sodium/glucose cotransporter 2 | 1 |
Data from ChEMBL 36 via Core Engine