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Compound Detail

CHEMBL4298153

NIROGACESTAT HYDROBROMIDE
💊 Approved Drug
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💊 Approved Drug
Br.Br.CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CNCC(C)(C)C)cn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4298153
Name NIROGACESTAT HYDROBROMIDE
Phase Approved
Structure Type MOL
InChI Key LXEYYZYDWLAIPW-KBVFCZPLSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL1770916
Active Moiety CHEMBL1770916

Known Names

Nirogacestat dihydrobromide Nirogacestat hydrobromide Ogsiveo PF-03084014-04
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
4
Known Names
2
Indications
1
Mechanisms

Molecular Properties

489.7
MW (Da)
4.79
ALogP
5
HBA
3
HBD
71.0
PSA (Ų)
0.45
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2023
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

First in Class
USAN Stem -stat
USAN Year 2018

Extended Properties

Molecular Formula C27H43Br2F2N5O
MW 651.48
Aromatic Rings 2
Heavy Atoms 35
NP-Likeness -0.89

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Gamma-secretase inhibitor INHIBITOR Gamma-secretase ✓ ✓

Indications

Desmoid Tumors Neoplasms

Data from ChEMBL 36 via Core Engine