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Compound Detail

CHEMBL4298171

LINZAGOLIX CHOLINE
💊 Approved Drug
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💊 Approved Drug
COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)[O-])c3c2=O)cc1OCc1c(OC)ccc(F)c1F.C[N+](C)(C)CCO
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4298171
Name LINZAGOLIX CHOLINE
Phase Approved
Structure Type MOL
InChI Key IAIVRTFCYOGNBW-UHFFFAOYSA-M
Therapeutic ✓ Yes
Parent Compound CHEMBL3668014
Active Moiety CHEMBL3668014

Known Names

KLH-2109 choline Linzagolix choline OBE2109 choline Yselty
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
4
Known Names
2
Indications
1
Mechanisms

Molecular Properties

508.4
MW (Da)
3.45
ALogP
8
HBA
2
HBD
119.8
PSA (Ų)
0.39
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2022
Availability Unknown
Chirality Achiral
USAN Stem -golix
USAN Year 2019

Extended Properties

Molecular Formula C27H28F3N3O8S
MW 611.60
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -1.00

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Gonadotropin-releasing hormone receptor antagonist ANTAGONIST Gonadotropin-releasing hormone receptor ✓ ✓

Indications

Leiomyoma Endometriosis

Data from ChEMBL 36 via Core Engine