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Compound Detail

CHEMBL4302259

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Nc1nccc(-c2c[nH]c3cc(I)ccc23)n1

Basic Information

ChEMBL ID CHEMBL4302259
Phase Preclinical
Structure Type MOL
InChI Key YTMBUIKYQAVTAV-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

336.1
MW (Da)
2.81
ALogP
3
HBA
2
HBD
67.6
PSA (Ų)
0.67
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H9IN4
MW 336.14
Aromatic Rings 3
Heavy Atoms 17
NP-Likeness -0.77

Activity Summary

EC50 1 meas. best 4.53
IC50 1 meas. best 4.88

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycolicibacterium smegmatis
CHEMBL613088
IC50 4.88 4.88 13200.0 1
Mycolicibacterium smegmatis
CHEMBL613088
EC50 4.53 4.53 29400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33479607 10.1039/c9md00466a Mycolicibacterium smegmatis 13

Data from ChEMBL 36 via Core Engine