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Compound Detail

CHEMBL430650

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CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O

Basic Information

ChEMBL ID CHEMBL430650
Phase Preclinical
Structure Type BOTH
InChI Key RZBJNEWMGZLTHV-VPFUYYLISA-N
0
Targets
0
Activities
0
Assay Types
1
PK Parameters
2
Publications
0
Known Names

Molecular Properties

821.9
MW (Da)
-1.52
ALogP
12
HBA
10
HBD
344.4
PSA (Ų)
0.04
QED
3
Ro5 Violations
25
Rot. Bonds

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H59N9O12
MW 821.93
Aromatic Rings 1
Heavy Atoms 58
NP-Likeness -0.08

Pharmacokinetic Data

Parameter Value Units Species
KA 2490.0 nm -

Literature References

PubMed DOI Target Context # Activities
10425111 10.1021/jm9807151 Substance-K receptor 2
10425111 10.1021/jm9807151 ADMET 1

Data from ChEMBL 36 via Core Engine