Compound Detail
CHEMBL430892
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Basic Information
| ChEMBL ID | CHEMBL430892 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GQBIMIUJNCVMCR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
468.8
MW (Da)
3.92
ALogP
7
HBA
0
HBD
64.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL4649 | Ki | 8.72 | 8.72 | 1.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 1.9 | nM | 8.72 | Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determine... | 12904058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12904058 | 10.1021/jm034077k | Corticotropin-releasing factor receptor 1 | 1 |
| 12904058 | 10.1021/jm034077k | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine