Compound Detail
CHEMBL437348
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCC(=O)NCCCCCC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4I)NC(=O)[C@@H]([C@@H](C)O)NC2=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(N)=O)CSSC[C@@H](N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc2ccccc2)C(=O)N3)cc1
Basic Information
| ChEMBL ID | CHEMBL437348 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQSCCVSVSHVPDQ-FLCPBSGFSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
1645.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.06
IC50 1 meas. best 8.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 1 CHEMBL1917 | IC50 | 8.21 | 8.21 | 6.1 | 1 |
| Unchecked CHEMBL612545 | EC50 | 8.06 | 8.06 | 8.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 1 | IC50 | = | 6.1 | nM | 8.21 | Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin rec... | 15658865 |
| Unchecked | EC50 | = | 8.8 | nM | 8.06 | Effective concentration of compound against forskolin stimulated cAMP production... | 15658865 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15658865 | 10.1021/jm049519m | Somatostatin receptor type 1 | 1 |
| 15658865 | 10.1021/jm049519m | Somatostatin receptor type 2 | 1 |
| 15658865 | 10.1021/jm049519m | Somatostatin receptor type 3 | 1 |
| 15658865 | 10.1021/jm049519m | Somatostatin receptor type 4 | 1 |
| 15658865 | 10.1021/jm049519m | Somatostatin receptor type 5 | 1 |
| 15658865 | 10.1021/jm049519m | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine