Compound Detail
CHEMBL439652
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Basic Information
| ChEMBL ID | CHEMBL439652 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IHTLSVJOEYCUQX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
377.9
MW (Da)
4.94
ALogP
2
HBA
1
HBD
59.9
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 5.79 | 5.79 | 1628.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 1628.0 | nM | 5.79 | Concentration required for the inhibitory activity against human Farnesyltransfe... | 11294379 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11294379 | 10.1016/s0960-894x(01)00061-0 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine