Compound Detail
CHEMBL440365
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CN(C)c1ccc(C/N=C(/NC#N)N2CCC(=C3c4ccc(Cl)cc4CCc4cc(Br)cnc43)CC2)cc1
Basic Information
| ChEMBL ID | CHEMBL440365 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KZVFXLKTHYAUEE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
590.0
MW (Da)
6.19
ALogP
4
HBA
1
HBD
67.5
PSA (Ų)
0.17
QED
2
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 100.0 | nM | 7.0 | FPT inhibitory activity was determined by the ability to inhibit the transfer of... | 11844681 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11844681 | 10.1016/s0960-894x(01)00826-5 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine