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Compound Detail

CHEMBL44081

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CCCCCCCCCCCCCCCOC(=O)CC(CO)CCn1cnc2c(O)nc(N)nc21

Basic Information

ChEMBL ID CHEMBL44081
Phase Preclinical
Structure Type MOL
InChI Key RLNVAGMPOMVYBV-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

491.7
MW (Da)
5.14
ALogP
9
HBA
3
HBD
136.4
PSA (Ų)
0.17
QED
1
Ro5 Violations
20
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H45N5O4
MW 491.68
Aromatic Rings 2
Heavy Atoms 35
NP-Likeness -0.02

Activity Summary

IC50 2 meas. best 4.48

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vero
CHEMBL391
IC50 4.48 4.48 33000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Vero IC50 = 33000.0 nM 4.48 Compound was tested for antiviral activity against Herpes Simplex virus Type-1(H... 3040998

Literature References

PubMed DOI Target Context # Activities
3040998 10.1021/jm00392a020 Vero 2

Data from ChEMBL 36 via Core Engine