Compound Detail
CHEMBL441223
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CCOc1nc2c(n1Cc1ccc(OC)c(Br)c1)C(=O)N(CC)C1=N[C@@H]3CCC[C@@H]3N12
Basic Information
| ChEMBL ID | CHEMBL441223 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LUSMKVRUULITST-CVEARBPZSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
488.4
MW (Da)
3.67
ALogP
7
HBA
0
HBD
72.2
PSA (Ų)
0.62
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.27 | 8.27 | 5.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 5.4 | nM | 8.27 | Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzyme | 14980684 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 5.37 | nM | 8.27 | Inhibition of PDE5 | 18045743 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14980684 | 10.1016/j.bmcl.2003.12.027 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 14980684 | 10.1016/j.bmcl.2003.12.027 | Phosphodiesterases; PDE5 & PDE6 | 1 |
| 18045743 | 10.1016/j.ejmech.2007.10.019 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 18045743 | 10.1016/j.ejmech.2007.10.019 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine