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Compound Detail

CHEMBL442191

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C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O

Basic Information

ChEMBL ID CHEMBL442191
Phase Preclinical
Structure Type MOL
InChI Key GMRQFYUYWCNGIN-WJBPREEXSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

416.6
MW (Da)
5.70
ALogP
3
HBA
3
HBD
60.7
PSA (Ų)
0.52
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C27H44O3
MW 416.65
Aromatic Rings 0
Heavy Atoms 30
NP-Likeness 2.65

Literature References

PubMed DOI Target Context # Activities
16480267 10.1021/jm050795q Vitamin D3 receptor 3
10893309 10.1021/jm0000160 Unchecked 2
10230636 10.1016/s0960-894x(99)00129-8 Vitamin D3 receptor 1
10230636 10.1016/s0960-894x(99)00129-8 Vitamin D-binding protein 1
14505658 10.1016/s0960-894x(03)00739-x Vitamin D3 receptor 1
14505658 10.1016/s0960-894x(03)00739-x HL-60 1
10479287 10.1021/jm980736v Vitamin D3 receptor 1
10479287 10.1021/jm980736v Vitamin D-binding protein 1
10479287 10.1021/jm980736v HL-60 1
10479287 10.1021/jm980736v Mus musculus 1
10893309 10.1021/jm0000160 Vitamin D-binding protein 1
10893309 10.1021/jm0000160 Vitamin D3 receptor 1

Data from ChEMBL 36 via Core Engine