Compound Detail
CHEMBL4439926
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Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL4439926 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MIORZWSPBNFZCY-SANMLTNESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
658.6
MW (Da)
4.59
ALogP
9
HBA
1
HBD
119.6
PSA (Ų)
0.16
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor CHEMBL1855 | IC50 | 6.94 | 6.94 | 115.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | IC50 | = | 115.0 | nM | 6.94 | Antagonist activity against human GnRH receptor expressed in HEK293 cells co-tra... | 27608177 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27608177 | 10.1021/acs.jmedchem.6b01071 | Gonadotropin-releasing hormone receptor | 2 |
Data from ChEMBL 36 via Core Engine