Compound Detail
CHEMBL4444976
CCX354 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4444976 |
| Name | CCX354 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ZIMLRKWQDLVPEK-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
5
Known Names
1
Indications
1
Mechanisms
Molecular Properties
451.9
MW (Da)
2.83
ALogP
7
HBA
1
HBD
92.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| C-C chemokine receptor type 1 antagonist | ANTAGONIST | C-C chemokine receptor type 1 | ✓ | ✓ |
Indications
Arthritis, Rheumatoid
Activity Summary
IC50 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| C-C chemokine receptor type 1 CHEMBL2413 | IC50 | 8.7 | 8.55 | 2.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| C-C chemokine receptor type 1 | IC50 | = | 2.0 | nM | 8.7 | Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adhere... | 30455146 |
| C-C chemokine receptor type 1 | IC50 | = | 4.0 | nM | 8.4 | Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemot... | 30455146 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30455146 | 10.1016/j.bmcl.2018.11.015 | C-C chemokine receptor type 1 | 2 |
| 30595446 | 10.1016/j.bmcl.2018.12.024 | Homo sapiens | 1 |
| 30455146 | 10.1016/j.bmcl.2018.11.015 | Homo sapiens | 1 |
Data from ChEMBL 36 via Core Engine