Compound Detail
CHEMBL4446067
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Basic Information
| ChEMBL ID | CHEMBL4446067 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIUZQCRIIBPLIJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
384.5
MW (Da)
3.08
ALogP
5
HBA
2
HBD
95.4
PSA (Ų)
0.58
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 5A CHEMBL2424504 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 5A | IC50 | = | 170.0 | nM | 6.77 | Inhibition of human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed ... | 30745098 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30745098 | 10.1016/j.bmc.2019.02.006 | Lysine-specific demethylase 5A | 3 |
Data from ChEMBL 36 via Core Engine