Compound Detail
CHEMBL4446667
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Basic Information
| ChEMBL ID | CHEMBL4446667 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BPWKTWGLXFWEGW-PHIMTYICSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
365.8
MW (Da)
3.21
ALogP
6
HBA
2
HBD
62.3
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| B-cell lymphoma 6 protein CHEMBL4105786 | IC50 | 6.11 | 6.11 | 770.0 | 1 |
| BCL-6/NCOR2 CHEMBL4523673 | IC50 | 6.11 | 6.11 | 770.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| B-cell lymphoma 6 protein | IC50 | = | 770.0 | nM | 6.11 | Inhibition of recombinant human C-terminal GST-tagged BCL6 BTB domain C8Q/C67R/C... | 31895575 |
| BCL-6/NCOR2 | IC50 | = | 770.0 | nM | 6.11 | Inhibition of BCL6/SMRT protein protein interaction (unknown origin) by TR-FRET ... | 33844535 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31895575 | 10.1021/acs.jmedchem.9b01618 | B-cell lymphoma 6 protein | 5 |
| 33844535 | 10.1021/acs.jmedchem.0c01686 | BCL-6/NCOR2 | 1 |
Data from ChEMBL 36 via Core Engine