Compound Detail
CHEMBL444814
L-CITRULLINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL444814 |
| Name | L-CITRULLINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | RHGKLRLOHDJJDR-BYPYZUCNSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
16
Indications
Molecular Properties
175.2
MW (Da)
-1.15
ALogP
3
HBA
4
HBD
118.4
PSA (Ų)
0.39
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Acute Lung Injury Postpoliomyelitis Syndrome Asthma Intermittent Claudication Neoplasms Peripheral Arterial Disease Respiratory Insufficiency Aging Anemia, Sickle Cell Bronchopulmonary Dysplasia Diabetes Mellitus, Type 2 Endocardial Cushion Defects Heart Septal Defects, Atrial Heart Septal Defects, Ventricular Hypertension MELAS Syndrome
Activity Summary
Kd 1 meas. best 4.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| No relevant target CHEMBL2362975 | Kd | 4.17 | 4.17 | 68000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| No relevant target | Kd | = | 68000.0 | nM | 4.17 | Dissociation constant of the compound | 15293991 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19060912 | 10.1038/nchembio.132 | General amino-acid permease GAP1 | 83 |
| 19060912 | 10.1038/nchembio.132 | Unchecked | 4 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 15293991 | 10.1021/jm030650o | No relevant target | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent dopamine transporter | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Estrogen receptor | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent noradrenaline transporter | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent serotonin transporter | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
Data from ChEMBL 36 via Core Engine