Compound Detail
CHEMBL4448942
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4448942 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AUHTXVYDYYFURI-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
367.5
MW (Da)
3.76
ALogP
3
HBA
0
HBD
53.0
PSA (Ų)
0.82
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 CHEMBL5464 | IC50 | 8.0 | 6.5667 | 10.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H... | 31013427 |
| Receptor-interacting serine/threonine-protein kinase 1 | IC50 | = | 794.0 | nM | 6.1 | Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculov... | 31013427 |
| Receptor-interacting serine/threonine-protein kinase 1 | IC50 | = | 2511.0 | nM | 5.6 | Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph... | 31013427 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31013427 | 10.1021/acs.jmedchem.9b00318 | Receptor-interacting serine/threonine-protein kinase 1 | 3 |
| 31013427 | 10.1021/acs.jmedchem.9b00318 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine