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Compound Detail

CHEMBL445118

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CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H]1COCCCN(C(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)[C@H](C)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)OC

Basic Information

ChEMBL ID CHEMBL445118
Phase Preclinical
Structure Type MOL
InChI Key GTUGRJBQGCGAQL-OOAKFPIBSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

827.0
MW (Da)
1.54
ALogP
11
HBA
6
HBD
239.2
PSA (Ų)
0.13
QED
3
Ro5 Violations
16
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C41H62N8O10
MW 826.99
Aromatic Rings 2
Heavy Atoms 59
NP-Likeness -0.18

Literature References

PubMed DOI Target Context # Activities
3276890 10.1021/jm00397a003 Renin 2
3276890 10.1021/jm00397a003 Pepsin A 2
3276890 10.1021/jm00397a003 Cathepsin D 2
3276890 10.1021/jm00397a003 Renin-1 1

Data from ChEMBL 36 via Core Engine