Compound Detail
CHEMBL445185
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL445185 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WNSBUBHOLORHPN-CVEARBPZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
239.3
MW (Da)
3.47
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of norepinephrine uptake at human NET in human HEK293 cells | 18550369 |
| Sodium-dependent dopamine transporter | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of dopamine uptake at human DAT in human HEK293 cells | 18550369 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18550369 | 10.1016/j.bmcl.2008.05.057 | Sodium-dependent noradrenaline transporter | 1 |
| 18550369 | 10.1016/j.bmcl.2008.05.057 | Sodium-dependent serotonin transporter | 1 |
| 18550369 | 10.1016/j.bmcl.2008.05.057 | Sodium-dependent dopamine transporter | 1 |
Data from ChEMBL 36 via Core Engine