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Compound Detail

CHEMBL4454283

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CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ccnc(Cl)c3)c(F)c1)c(C)n2C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4454283
Phase Preclinical
Structure Type MOL
InChI Key DJLUDBVDNXFCRW-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

465.9
MW (Da)
5.64
ALogP
5
HBA
1
HBD
73.2
PSA (Ų)
0.39
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H21ClFN3O3
MW 465.91
Aromatic Rings 4
Heavy Atoms 33
NP-Likeness -1.42

Literature References

PubMed DOI Target Context # Activities
27379978 10.1021/acs.jmedchem.6b00608 Tyrosine-protein kinase receptor UFO 1

Data from ChEMBL 36 via Core Engine