Compound Detail

CHEMBL4459781

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ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4459781
Phase	Preclinical
Structure Type	MOL
InChI Key	FQLXMXKXZYIXBI-AZOSUDMBSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

4493.8

MW (Da)

Drug Information

Molecule Type	Unknown
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C182H263N51O71S6
MW	4493.79

Activity Summary

IC50 2 meas. best 7.7

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Sclerostin CHEMBL3580487	IC50	7.7	7.7	20.0	1
Sclerostin CHEMBL4523438	IC50	7.7	7.7	20.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Sclerostin	IC50	=	20.0	nM	7.7	Inhibition of biotin-labeled rat recombinant sclerostin assessed as reduction in...	-
Sclerostin	IC50	=	20.0	nM	7.7	Inhibition of biotin-labeled human recombinant sclerostin assessed as reduction ...	-

Data from ChEMBL 36 via Core Engine