Compound Detail
CHEMBL4463202
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Basic Information
| ChEMBL ID | CHEMBL4463202 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OZRNKXFMUVNVFC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
380.4
MW (Da)
4.70
ALogP
4
HBA
1
HBD
67.8
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine CHEMBL1255164 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine | IC50 | = | 0.2 | nM | 9.7 | Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with ... | 27437076 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27437076 | 10.1021/acsmedchemlett.6b00038 | No relevant target | 1 |
| 27437076 | 10.1021/acsmedchemlett.6b00038 | Protein-serine O-palmitoleoyltransferase porcupine | 1 |
Data from ChEMBL 36 via Core Engine