Compound Detail
CHEMBL4464704
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Basic Information
| ChEMBL ID | CHEMBL4464704 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JIMPMJAEPCESCM-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
333.1
MW (Da)
1.13
ALogP
4
HBA
3
HBD
90.1
PSA (Ų)
0.53
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 4.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cytosol aminopeptidase CHEMBL5624 | IC50 | 4.2 | 4.2 | 63580.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cytosol aminopeptidase | IC50 | = | 63580.0 | nM | 4.2 | Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoum... | 27624521 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27624521 | 10.1016/j.bmc.2016.08.054 | Cytosol aminopeptidase | 1 |
| 27624521 | 10.1016/j.bmc.2016.08.054 | MCF7 | 1 |
| 27624521 | 10.1016/j.bmc.2016.08.054 | MCF10 | 1 |
| 27624521 | 10.1016/j.bmc.2016.08.054 | Unchecked | 1 |
| 27624521 | 10.1016/j.bmc.2016.08.054 | HL-60 | 1 |
| 27624521 | 10.1016/j.bmc.2016.08.054 | HL60/MX2 | 1 |
| 27624521 | 10.1016/j.bmc.2016.08.054 | BALB/3T3 | 1 |
Data from ChEMBL 36 via Core Engine