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Compound Detail

CHEMBL4465651

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O=c1oc2c(Br)c(O)ccc2c2ccc(O)cc12

Basic Information

ChEMBL ID CHEMBL4465651
Phase Preclinical
Structure Type MOL
InChI Key PUIGXVQKZSAMTP-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

307.1
MW (Da)
3.12
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.49
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H7BrO4
MW 307.10
Aromatic Rings 3
Heavy Atoms 18
NP-Likeness 0.80

Activity Summary

Ki 1 meas. best 8.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Casein kinase II subunit alpha
CHEMBL3629
Ki 8.15 8.15 7.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Casein kinase II subunit alpha Ki = 7.0 nM 8.15 Inhibition of CK2alpha (unknown origin) 31400711

Literature References

PubMed DOI Target Context # Activities
31400711 10.1016/j.ejmech.2019.111581 Casein kinase II subunit alpha 1

Data from ChEMBL 36 via Core Engine