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Compound Detail

CHEMBL446904

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Nc1c(S(=O)(=O)[O-])cc(Nc2ccc(Oc3ccccc3)c(S(=O)(=O)[O-])c2)c2c1C(=O)c1ccccc1C2=O.[Na+].[Na+]

Basic Information

ChEMBL ID CHEMBL446904
Phase Preclinical
Structure Type MOL
InChI Key LDZJKFJKNJBGQH-UHFFFAOYSA-L
Parent Compound CHEMBL1207855
Active Moiety CHEMBL1207855
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

566.6
MW (Da)
4.07
ALogP
9
HBA
4
HBD
190.2
PSA (Ų)
0.17
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H16N2Na2O9S2
MW 610.53
Aromatic Rings 4
Heavy Atoms 39
NP-Likeness -0.33

Activity Summary

Ki 1 meas. best 7.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 12
CHEMBL2001
Ki 7.2 7.2 63.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
P2Y purinoceptor 12 Ki = 63.0 nM 7.2 Displacement of [3H]PSB0413 from human platelet P2Y12 receptor 19463000

Literature References

PubMed DOI Target Context # Activities
19463000 10.1021/jm9003297 P2Y purinoceptor 12 1

Data from ChEMBL 36 via Core Engine