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Compound Detail

CHEMBL447145

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CCN(CC)CC.Cc1cn([C@H]2C[C@H](OP(=O)(O)OC[C@H]3O[C@@H](n4cc(C)c(=O)[nH]c4=O)C[C@@H]3O)[C@@H](C(=O)NCCCCCCN[C@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)O2)c(=O)[nH]c1=O

Basic Information

ChEMBL ID CHEMBL447145
Phase Preclinical
Structure Type MOL
InChI Key OHYIOYRCPSBRJA-LFMGAYCLSA-N
Parent Compound CHEMBL1186047
Active Moiety CHEMBL1186047
0
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

963.0
MW (Da)
-5.69
ALogP
23
HBA
13
HBD
428.5
PSA (Ų)
0.05
QED
3
Ro5 Violations
19
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C44H78N11O17P
MW 1064.14
Aromatic Rings 2
Heavy Atoms 66
NP-Likeness 0.74

Activity Summary

Kd 3 meas.

Literature References

PubMed DOI Target Context # Activities
18829307 10.1016/j.bmcl.2008.09.062 Unchecked 4

Data from ChEMBL 36 via Core Engine