Compound Detail

CHEMBL4471871

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4471871
Phase	Preclinical
Structure Type	MOL
InChI Key	WNWLMMMHXDFXKP-MKFDRYHQSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

1837.1

MW (Da)

Drug Information

Molecule Type	Unknown
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C87H129N13O28S
MW	1837.12

Activity Summary

EC50 2 meas. best 9.77

IC50 2 meas. best 10.05

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Cholecystokinin receptor type A CHEMBL1901	IC50	10.05	10.05	0.1	1
Cholecystokinin receptor type A CHEMBL1901	EC50	9.77	9.77	0.2	1
Gastrin/cholecystokinin type B receptor CHEMBL298	EC50	8.81	8.81	1.5	1
Gastrin/cholecystokinin type B receptor CHEMBL298	IC50	6.61	6.61	245.5	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Cholecystokinin receptor type A	IC50	=	0.08913	nM	10.05	Displacement of [125I]-CCK-8 from human CCK1R expressed in human 1321N1 cell mem...	30624060
Cholecystokinin receptor type A	EC50	=	0.1698	nM	9.77	Agonist activity at human CCK1R expressed in human 1321N1 cells assessed as IP1 ...	30624060
Gastrin/cholecystokinin type B receptor	EC50	=	1.549	nM	8.81	Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 ...	30624060
Gastrin/cholecystokinin type B receptor	IC50	=	245.47	nM	6.61	Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell mem...	30624060

Literature References

PubMed	DOI	Target Context	# Activities
30624060	10.1021/acs.jmedchem.8b01558	Cholecystokinin receptor type A	2
30624060	10.1021/acs.jmedchem.8b01558	Gastrin/cholecystokinin type B receptor	2

Data from ChEMBL 36 via Core Engine