Compound Detail
CHEMBL447239
CINNABARAMIDE G Enter ChEMBL ID:
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CCCCCC[C@H]1C(=O)N[C@](C(=O)SC[C@H](NC(C)=O)C(=O)OC)([C@@H](O)[C@@H]2C=CCCC2)[C@@]1(C)O
Basic Information
| ChEMBL ID | CHEMBL447239 |
| Name | CINNABARAMIDE G |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GMTRMEITDRYTSO-YNCBRICXSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
512.7
MW (Da)
1.85
ALogP
8
HBA
4
HBD
142.0
PSA (Ų)
0.18
QED
1
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 20S proteasome CHEMBL3831201 | IC50 | 9.22 | 9.22 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 20S proteasome | IC50 | = | 0.6 | nM | 9.22 | Inhibition of human 20S proteasome | 17249727 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17249727 | 10.1021/np060162u | No relevant target | 2 |
| 17249727 | 10.1021/np060162u | Unchecked | 1 |
| 17249727 | 10.1021/np060162u | Trypsin | 1 |
| 17249727 | 10.1021/np060162u | 20S proteasome | 1 |
Data from ChEMBL 36 via Core Engine