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Compound Detail

CHEMBL4472590

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CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C

Basic Information

ChEMBL ID CHEMBL4472590
Phase Preclinical
Structure Type MOL
InChI Key NPIMHQRCKGHZLZ-TUVARWSOSA-N
0
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

1581.7
MW (Da)

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C64H104N22O25
MW 1581.66

Activity Summary

IC50 2 meas.

Literature References

PubMed DOI Target Context # Activities
36446632 10.1021/acs.jmedchem.2c01290 PCSK9/LDLR 3
30996774 10.1021/acsmedchemlett.8b00464 PCSK9/LDLR 2

Data from ChEMBL 36 via Core Engine