Compound Detail
CHEMBL4472616
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
O=C(Nc1ccc(Oc2ncnc3cc(OC4CCOCC4)c4c(c23)OCCO4)cc1)Nc1cc(C(F)(F)F)ccc1F
Basic Information
| ChEMBL ID | CHEMBL4472616 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HARFYYMEMIZMIG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
600.5
MW (Da)
6.55
ALogP
8
HBA
2
HBD
113.1
PSA (Ų)
0.24
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.95 | 7.95 | 11.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 11.2 | nM | 7.95 | Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356... | 31096155 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31096155 | 10.1016/j.ejmech.2019.04.015 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine