Compound Detail
CHEMBL4473253
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4473253 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SKSPKMMFLRTXTH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
425.5
MW (Da)
4.41
ALogP
6
HBA
1
HBD
81.9
PSA (Ų)
0.47
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 9.28 | 9.28 | 0.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 0.52 | nM | 9.28 | Inhibition of VEGFR2 (unknown origin) after 1 hr by ADP-Glo reagent based lumine... | 30503935 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30503935 | 10.1016/j.ejmech.2018.11.042 | Vascular endothelial growth factor receptor 2 | 1 |
| 30503935 | 10.1016/j.ejmech.2018.11.042 | Angiopoietin-1 receptor | 1 |
| 30503935 | 10.1016/j.ejmech.2018.11.042 | Ephrin type-B receptor 4 | 1 |
| 30503935 | 10.1016/j.ejmech.2018.11.042 | EA.hy 926 | 1 |
Data from ChEMBL 36 via Core Engine