Compound Detail
CHEMBL448126
SPONGIACIDIN C Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL448126 |
| Name | SPONGIACIDIN C |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MOYLWFAZPQYOGQ-VURMDHGXSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
246.2
MW (Da)
-0.30
ALogP
3
HBA
4
HBD
103.1
PSA (Ų)
0.37
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 7 CHEMBL2157850 | IC50 | 5.42 | 5.42 | 3800.0 | 1 |
| Ubiquitin carboxyl-terminal hydrolase 21 CHEMBL2157852 | IC50 | 4.78 | 4.78 | 16600.0 | 1 |
| Protein kinase C (PKC) CHEMBL2093867 | IC50 | 4.66 | 4.66 | 22000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 3800.0 | nM | 5.42 | Inhibition of USP7 (unknown origin) using ubiquitin-EKL as substrate | 23684893 |
| Ubiquitin carboxyl-terminal hydrolase 21 | IC50 | = | 16600.0 | nM | 4.78 | Inhibition of core catalytic domain of USP21 (unknown origin) using ubiquitin-Rh... | 23684893 |
| Protein kinase C (PKC) | IC50 | = | 22000.0 | nM | 4.66 | Inhibition of Protein kinase C (unknown origin) | 33901899 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9599282 | 10.1021/np970565h | Receptor tyrosine-protein kinase erbB-2 | 1 |
| 9599282 | 10.1021/np970565h | Cyclin-dependent kinase 4 | 1 |
| 23684893 | 10.1016/j.bmcl.2013.04.066 | HCT-116 | 1 |
| 23684893 | 10.1016/j.bmcl.2013.04.066 | Sentrin-specific protease 1 | 1 |
| 23684893 | 10.1016/j.bmcl.2013.04.066 | Ubiquitin carboxyl-terminal hydrolase 21 | 1 |
| 23684893 | 10.1016/j.bmcl.2013.04.066 | Ubiquitin carboxyl-terminal hydrolase 8 | 1 |
| 23684893 | 10.1016/j.bmcl.2013.04.066 | Ubiquitin carboxyl-terminal hydrolase 2 | 1 |
| 23684893 | 10.1016/j.bmcl.2013.04.066 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 33901899 | 10.1016/j.ejmech.2021.113445 | Protein kinase C (PKC) | 1 |
Data from ChEMBL 36 via Core Engine