Compound Detail
CHEMBL449884
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COc1ccc(O[C@H]2C=C[C@@H](c3ccccc3)O[C@@H]2CO/N=C2/[C@H]3CCn4c(=O)n(-c5ccccc5)c(=O)n4[C@H]3[C@H](O)[C@@H]3O[C@H]23)cc1
Basic Information
| ChEMBL ID | CHEMBL449884 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JMHXWPSJVFXBGB-MHWGFBSGSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
638.7
MW (Da)
3.03
ALogP
12
HBA
1
HBD
131.0
PSA (Ų)
0.18
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis C virus CHEMBL379 | EC50 | 5.58 | 5.58 | 2600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatitis C virus | EC50 | = | 2600.0 | nM | 5.58 | Antiviral activity against HCV replication in human HuH7 cells expressing Rep-Fe... | 17682098 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17682098 | 10.1128/aac.00233-07 | Hepatitis C virus | 1 |
| 17682098 | 10.1128/aac.00233-07 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine