Compound Detail
CHEMBL451321
METAGLIDASEN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL451321 |
| Name | METAGLIDASEN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DDTQLPXXNHLBAB-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
330.7
MW (Da)
4.56
ALogP
2
HBA
1
HBD
46.5
PSA (Ų)
0.89
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.0
IC50 1 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | IC50 | 6.66 | 6.66 | 220.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | IC50 | = | 220.0 | nM | 6.66 | Antagonist activity at human PPARgamma receptor expressed in Saccharomyces cerev... | 18329752 |
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 10000.0 | nM | 5.0 | Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed ... | 22341573 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 490551 | 10.1021/jm00195a011 | Rattus norvegicus | 6 |
| 22341573 | 10.1016/j.bmc.2012.01.025 | Peroxisome proliferator-activated receptor alpha | 2 |
| 22341573 | 10.1016/j.bmc.2012.01.025 | Peroxisome proliferator-activated receptor gamma | 2 |
| 18329752 | 10.1016/j.ejmech.2008.01.032 | Peroxisome proliferator-activated receptor gamma | 1 |
Data from ChEMBL 36 via Core Engine