Compound Detail
CHEMBL4515559
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N=C(N)NCCC[C@@H]1NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N2
Basic Information
| ChEMBL ID | CHEMBL4515559 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BFQYCHQCQCZVFJ-APKGMPDHSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1605.9
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasminogen CHEMBL1801 | Ki | 8.74 | 8.74 | 1.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasminogen | Ki | = | 1.8 | nM | 8.74 | Inhibition of human plasmin using Ac-RM(O2)YR-pNA as substrate after 30 mins | 30520638 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30520638 | 10.1021/acs.jmedchem.8b01139 | Plasminogen | 1 |
Data from ChEMBL 36 via Core Engine