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Compound Detail

CHEMBL4515639

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C=C(c1ccccc1)[C@@]12CC[C@H](NS(N)(=O)=O)[C@@H]1CC(CCCCCCCCCC(=O)Nc1ccc3c(c1)C(=O)OC31c3ccc(O)cc3Oc3cc(O)ccc31)=C2c1ccccc1

Basic Information

ChEMBL ID CHEMBL4515639
Phase Preclinical
Structure Type MOL
InChI Key CXVIXELBRGYJOW-OCTREFHSSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

880.1
MW (Da)
10.24
ALogP
8
HBA
5
HBD
177.3
PSA (Ų)
0.05
QED
2
Ro5 Violations
16
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C52H53N3O8S
MW 880.08
Aromatic Rings 5
Heavy Atoms 64
NP-Likeness 0.17

Activity Summary

Kd 3 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 5 group A member 2
CHEMBL3544
Kd 9.0 8.66 1.0 2
Steroidogenic factor 1
CHEMBL4666
Kd 7.91 7.91 12.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32184971 10.1021/acsmedchemlett.9b00442 Nuclear receptor subfamily 5 group A member 2 2
32184971 10.1021/acsmedchemlett.9b00442 Steroidogenic factor 1 1

Data from ChEMBL 36 via Core Engine