Compound Detail
CHEMBL4516637
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Basic Information
| ChEMBL ID | CHEMBL4516637 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RCHPGNATOYICNX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
222.2
MW (Da)
1.14
ALogP
5
HBA
1
HBD
92.7
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 8 CHEMBL2157854 | IC50 | 4.32 | 4.32 | 48000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 8 | IC50 | = | 48000.0 | nM | 4.32 | Inhibition of human USP8 using Ub-AMC as substrate | 32092586 |
| Ubiquitin carboxyl-terminal hydrolase 8 | IC50 | = | 48000.0 | nM | 4.32 | Inhibition of USP8 (unknown origin) | 32092586 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30508483 | 10.1021/acs.jmedchem.8b01424 | NAD(P)H dehydrogenase [quinone] 1 | 2 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 8 | 2 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 47 | 1 |
Data from ChEMBL 36 via Core Engine