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Compound Detail

CHEMBL4520346

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Nc1cccc2c1C(=O)N(C1CC(=O)NC1=O)C2=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4520346
Phase Preclinical
Structure Type MOL
InChI Key MSHTVRYXGFREAN-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

259.2
MW (Da)
-0.72
ALogP
5
HBA
2
HBD
109.6
PSA (Ų)
0.51
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H9N3O4
MW 259.22
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -0.23

Literature References

PubMed DOI Target Context # Activities
31251063 10.1021/acs.jmedchem.9b00454 Cereblon isoform 4 1
31251063 10.1021/acs.jmedchem.9b00454 Cereblon/Casein kinase I alpha 1
31251063 10.1021/acs.jmedchem.9b00454 Protein cereblon/Aiolos 1

Data from ChEMBL 36 via Core Engine