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Compound Detail

CHEMBL4525617

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CC(=O)Nc1ccc(-c2nc3ccc(O)cc3s2)cc1

Basic Information

ChEMBL ID CHEMBL4525617
Phase Preclinical
Structure Type MOL
InChI Key QEEIHQGEPSKXFB-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

284.3
MW (Da)
3.63
ALogP
4
HBA
2
HBD
62.2
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H12N2O2S
MW 284.34
Aromatic Rings 3
Heavy Atoms 20
NP-Likeness -1.63

Activity Summary

Ki 1 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sulfotransferase 1A1
CHEMBL1743291
Ki 7.0 7.0 100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Sulfotransferase 1A1 Ki = 100.0 nM 7.0 Inhibition of SULT1A1 (unknown origin) expressed in baculovirus infected Sf9 cel... -

Data from ChEMBL 36 via Core Engine