Compound Detail
CHEMBL4531811
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CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC1CCC(C2CCCCC2)CC1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)[C@@]1(C)CO1
Basic Information
| ChEMBL ID | CHEMBL4531811 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IUGFRSHEZUIDNH-NCQYJYCGSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
727.0
MW (Da)
6.79
ALogP
6
HBA
3
HBD
165.7
PSA (Ų)
0.07
QED
2
Ro5 Violations
18
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 7.77 | 7.065 | 17.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 | IC50 | = | 17.0 | nM | 7.77 | Inhibition of catalytic activity of constitutive proteasome 20s subunit beta5 in... | 27438186 |
| Proteasome Macropain subunit MB1 | IC50 | = | 439.0 | nM | 6.36 | Inhibition of catalytic activity of immunoproteasome 20s subunit beta5 in human ... | 27438186 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27438186 | 10.1021/acs.jmedchem.6b00705 | Proteasome Macropain subunit MB1 | 4 |
| 27438186 | 10.1021/acs.jmedchem.6b00705 | Proteasome Macropain subunit | 4 |
| 27438186 | 10.1021/acs.jmedchem.6b00705 | Proteasome component C5 | 4 |
| 27438186 | 10.1021/acs.jmedchem.6b00705 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine