Compound Detail
CHEMBL4535893
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Basic Information
| ChEMBL ID | CHEMBL4535893 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WYWAZZIFKZZVRR-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
245.2
MW (Da)
1.75
ALogP
3
HBA
3
HBD
90.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polymerase acidic protein CHEMBL1169598 | IC50 | 8.14 | 8.12 | 7.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polymerase acidic protein | IC50 | = | 7.2 | nM | 8.14 | Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endon... | 31536340 |
| Polymerase acidic protein | IC50 | = | 7.943 | nM | 8.1 | Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endon... | 31536340 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31536340 | 10.1021/acs.jmedchem.9b00747 | Polymerase acidic protein | 3 |
Data from ChEMBL 36 via Core Engine